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The San Francisco 49ers (4-1) will lock horns with the Tampa Bay Buccaneers (4-1) in Week 6 of the 2025 NFL season on Sunday. The game will kick off at 4:25 p.m. ET from Raymond James Stadium in Tampa, Florida.
Ahead of the 49ers vs. Buccaneers game, here's a look at the projected lineups for both teams.
San Francisco 49ers vs. Tampa Bay Buccaneers projected starting lineup for Week 6
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San Francisco 49ers projected starting lineup
NFL: San Francisco 49ers RB Christian McCaffrey - Source: ImagnLooking to predict NFL playoff Scenarios? Try our NFL Playoff Predictor for real-time simulations and stay ahead of the game!
Here's a look at the 49ers' projected starters on offense vs. the Buccaneers:
| QB | Mac Jones |
| RB | Christian McCaffrey |
| WR (X) | Jauan Jennings |
| WR (Z) | Skyy Moore |
| WR (SL) | Kendrick Bourne |
| TE | Jake Tonges |
| FB | Kyle Juszczyk |
| LT | Trent Williams |
| LG | Connor Colby |
| C | Jake Brendel |
| RG | Dominick Puni |
| RT | Colton McKivitz |
Here's a look at the 49ers' projected starters on defense vs. the Buccaneers:
| LDE | Bryce Huff |
| LDT | Kalia Davis |
| RDT | Jordan Elliott |
| RDE | Mykel Williams |
| WLB | Dee Winters |
| MLB | Fred Warner |
| SLB | Luke Gifford |
| LCB | Renardo Green |
| SS | Marques Sigle |
| FS | Jason Pinnock |
| RCB | Deommodore Lenoir |
| NB | Upton Stout |
Here's a look at the 49ers' projected starters on special teams vs. the Buccaneers:
| PK | Eddy Pineiro |
| P | Thomas Morstead |
| H | Thomas Morstead |
| PR | Skyy Moore |
| KR | Isaac Guerendo |
| LS | Jon Weeks |
Tampa Bay Buccaneers projected starting lineup
Tampa Bay Buccaneers QB Baker Mayfield - NFL 2025 - Source: GettyHere's a look at the Buccaneers' projected starters on offense vs. the 49ers:
| QB | Baker Mayfield |
| RB | Rachaad White |
| WR (X) | Sterling Shepard |
| WR (Z) | Tez Johnson |
| WR (SL) | Emeka Egbuka |
| TE | Cade Otton |
| LT | Tristan Wirfs |
| LG | Ben Bredeson |
| C | Graham Barton |
| RG | Luke Haggard |
| RT | Charlie Heck |
Here's a look at the Buccaneers' projected starters on defense vs. the 49ers:
| LDE | Elijah Roberts |
| NT | Vita Vea |
| RDE | Logan Hall |
| WLB | Yaya Diaby |
| LILB | SirVocea Dennis |
| RILB | Lavonte David |
| SLB | Haason Reddick |
| LCB | Jamel Dean |
| SS | Antoine Winfield Jr. |
| FS | Tykee Smith |
| RCB | Josh Hayes |
| NB | Jacob Parrish |
Here's a look at the Buccaneers' projected starters on special teams vs. the 49ers:
| PK | Chase McLaughlin |
| P | Riley Dixon |
| H | Riley Dixon |
| PR | Kameron Johnson |
| KR | Sean Tucker |
| LS | Evan Deckers |
San Francisco 49ers vs. Tampa Bay Buccaneers depth chart for Week 6
San Francisco 49ers depth chart
Here's a look at the 49ers' depth chart for their offense:
| QB | Brock Purdy (O) | Mac Jones (Q) | Adrian Martinez | Kurtis Rourke (O) |
| RB | Christian McCaffrey | Brian Robinson Jr. | Isaac Guerendo | Jordan James |
| WR (X) | Jauan Jennings (Q) | Demarcus Robinson | Jordan Watkins (O) | Trent Taylor (IR) |
| WR (Z) | Ricky Pearsall (O) | Skyy Moore | Brandon Aiyuk (O) | – |
| WR (SL) | Kendrick Bourne | Marquez Valdes-Scantling | Jacob Cowing (IR) | – |
| TE | Jake Tonges | Luke Farrell | Brayden Willis | George Kittle (IR) |
| FB | Kyle Juszczyk | – | – | – |
| LT | Trent Williams | Spencer Burford (IR) | – | – |
| LG | Connor Colby | Ben Bartch (IR) | – | – |
| C | Jake Brendel | Matt Hennessy | – | – |
| RG | Dominick Puni | Drew Moss | – | – |
| RT | Colton McKivitz | Austen Pleasants | Isaac Alarcon (SUSP) | – |
Here's a look at the 49ers' depth chart for their defense:
| LDE | Bryce Huff | Yetur Gross-Matos (O) | Tarron Jackson (IR) | – |
| LDT | Kalia Davis (Q) | Alfred Collins (Q) | Kevin Givens (IR) | – |
| RDT | Jordan Elliott | CJ West | – | – |
| RDE | Mykel Williams | Sam Okuayinonu | Trevis Gipson | Nick Bosa (IR) |
| WLB | Dee Winters | Nick Martin | – | – |
| MLB | Fred Warner | Tatum Bethune | – | – |
| SLB | Luke Gifford | Curtis Robinson | – | – |
| LCB | Renardo Green | Tre Tomlinson (IR) | – | – |
| SS | Marques Sigle | Ji’Ayir Brown | – | – |
| FS | Jason Pinnock | Malik Mustapha (Q) | Siran Neal | – |
| RCB | Deommodore Lenoir | Darrell Luter Jr. | Jakob Robinson (IR) | – |
| NB | Upton Stout (Q) | Chase Lucas | – | – |
Here's a look at the 49ers' depth chart for their special teams:
| PK | Eddy Pineiro | – | – | – |
| P | Thomas Morstead | – | – | – |
| H | Thomas Morstead | – | – | – |
| PR | Skyy Moore | Jordan Watkins (O) | Jacob Cowing (IR) | – |
| KR | Isaac Guerendo | Skyy Moore | – | – |
| LS | Jon Weeks | – | – | – |
Tampa Bay Buccaneers depth chart
Here's a look at the Buccaneers' depth chart for their offense:
| QB | Baker Mayfield | Teddy Bridgewater | – | – |
| RB | Bucky Irving (O) | Rachaad White | Sean Tucker | Josh Williams (O) |
| WR (X) | Mike Evans (O) | Sterling Shepard | Kameron Johnson | – |
| WR (Z) | Chris Godwin Jr. (O) | Tez Johnson | Jalen McMillan (IR) | – |
| WR (SL) | Emeka Egbuka | Ryan Miller | Jaden Smith (IR) | – |
| TE | Cade Otton | Payne Durham | Devin Culp | Ko Kieft (IR) |
| LT | Tristan Wirfs | Graham Barton | – | – |
| LG | Ben Bredeson | Elijah Klein | Mike Jordan | Dan Feeney |
| C | Graham Barton | Ben Bredeson | – | – |
| RG | Luke Haggard | Elijah Klein | Cody Mauch (IR) | – |
| RT | Charlie Heck | Benjamin Chukwuma | Luke Goedeke (IR) | – |
Here's a look at the Buccaneers' depth chart for their defense:
| LDE | Elijah Roberts | C.J. Brewer | Calijah Kancey (IR) | – |
| NT | Vita Vea | Elijah Simmons | – | – |
| RDE | Logan Hall | Greg Gaines | – | – |
| WLB | Yaya Diaby | Chris Braswell | David Walker (IR) | – |
| LILB | SirVocea Dennis | John Bullock | – | – |
| RILB | Lavonte David | Deion Jones | – | – |
| SLB | Haason Reddick | Anthony Nelson | Markees Watts | – |
| LCB | Jamel Dean | Benjamin Morrison (O) | – | – |
| SS | Antoine Winfield Jr. | Christian Izien (Q) | Sebastian Castro | JJ Roberts (IR) |
| FS | Tykee Smith | Kaevon Merriweather | Rashad Wisdom (IR) | – |
| RCB | Zyon McCollum (O) | Josh Hayes | – | – |
| NB | Jacob Parrish | Kindle Vildor | – | – |
Here's a look at the Buccaneers' depth chart for their special teams:
| PK | Chase McLaughlin | – | – | – |
| P | Riley Dixon | – | – | – |
| H | Riley Dixon | – | – | – |
| PR | Kameron Johnson | Rachaad White | Tez Johnson | Jalen McMillan (IR) |
| KR | Sean Tucker | Josh Williams (O) | Emeka Egbuka | Kameron Johnson |
| LS | Evan Deckers | – | – | – |
How to watch the San Francisco 49ers vs. Tampa Bay Buccaneers game? TV channel and live stream details for Week 6 contest
The 49ers vs. Buccaneers Week 6 game will be broadcast live on CBS. Fans can also live stream the contest on Paramount+ or Fubo.
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