With Kyler Murray inactive, Cards turn to Jacoby Brissett vs. Colts

Sep 25, 2025; Glendale, Arizona, USA; Arizona Cardinals quarterback Kyler Murray (1) and Jacoby Brissett (7) against the Seattle Seahawks at State Farm Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images

Arizona quarterback Jacoby Brissett will get the start against the host Indianapolis Colts on Sunday after the Cardinals listed Kyler Murray as inactive for the game.

Murray was questionable heading into the contest due to a foot injury suffered during the third quarter of last week's 22-21 loss at home against the Tennessee Titans.

Murray, 28, has not missed a game since sitting out Weeks 1-10 in 2023 while recovering from surgery for a torn ACL.

He has completed 68.3 percent of his passes for 962 yards with six touchdowns and three interceptions in five starts this season. He has rushed for 173 yards and one score for Arizona (2-3).

Brissett, 32, took most of the reps in practice this week. He has made 53 career NFL starts, with 30 coming during his time with the Colts from 2017-20.

The Cardinals signed quarterback Kedon Slovis to the 53-man active roster from the practice squad on Saturday.

--Field Level Media